- To proceed with the small sample size.
- To urgently advise that an underpowered study is unethical and a waste of resources, as it has a high chance of missing a true effect (Type II error).
- To only consider the cost of the trial.
- To assume the drug will work anyway.
193. A critical situational clinical trial is planned to assess a new drug. The biostatistician notes that the proposed sample size is too small to detect a clinically meaningful difference. What is the urgency for intervention?
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